What is
MSE?

Patient portrayal

The image above is a patient portrayal and partial depiction of the MG-ADL scale, which assesses the impact of gMG on daily functions of 8 signs or symptoms that are typically affected in gMG. Each function is scored from 0-3: 0 represents normal function and 3 represents the loss of ability to perform that function. A total score can range from 0 to 24.

gMG=generalized myasthenia gravis; MG-ADL=Myasthenia Gravis Activities of Daily Living.

MSE: a treatment goal to strive for

The term MSE is utilized to describe an MG-ADL score of 0 or 1, indicating that a patient has minimal or no symptoms.1,2

Aiming for MSE as the ultimate goal may allow patients to do more than manage their symptoms. It may give them the ability to get back to some of the daily activities that bring meaning to their lives.1

The image above is a patient portrayal and partial depiction of the MG-ADL scale, which assesses the impact of gMG on daily functions of 8 signs or symptoms that are typically affected in gMG. Each function is scored from 0-3: 0 represents normal function and 3 represents the loss of ability to perform that function. A total score can range from 0-24.

gMG=generalized myasthenia gravis; MG-ADL Myasthenia Gravis Activities of Daily Living; MSE=Minimal Symptom Expression.

MSE Aspirational Goal
After my diagnosis, I knew I wanted to aim for as many of those same daily activities as I possibly could, even with MG.

—Real patient living with gMG

In 4 clinical studies

The majority of patients using targeted therapies in conjunction
with traditional treatment saw their MG-ADL scores improve, with some observed to have reached MSE3-6*†

*Data was collected from 4 randomized, double-blind clinical trials (one phase 2 trial and three phase 3 trials) across 521 patients 18 years and older. Patients were on at least one standard-of-care therapy with MG-ADL baseline scores ranging from 5 to 11.3-6

†Targeted therapies are treatments that target the underlying pathophysiological pathways of the disease.7

MG-ADL=Myasthenia Gravis Activities of Daily Living; MSE=Minimal Symptom Expression.

Could prescribing targeted therapies alongside traditional therapies help your patients aim for a life with fewer symptoms?

Hear from experts about the benefits of utilizing
the MG-ADL scale and working toward MSE

Striving for Minimal Symptom Expression as a Treatment Goal in Myasthenia Gravis

Dr. Rosenfeld discusses the evolving treatment landscape with the goal of striving for MSE in more patients.

How to Administer and Use the MG-ADL Scale in Clinical Practice

Dr. Howard discusses MSE and walks through a useful way to use the MG-ADL scale in clinical practice.

gMG=generalized myasthenia gravis; MG-ADL=Myasthenia Gravis Activities of Daily Living; MSE=Minimal Symptom Expression.

References: 1. Muppidi S et al. Muscle Nerve. 2022;65(6):630-639. doi:10.1002/mus.27476 2. Uzawa A et al. Acta Neurol Belg. 2023;123(3):979-982. doi:10.1007/s13760-022-02162-1 3. Howard JF Jr et al. Lancet Neurol. 2021;20(7):526-536. doi:10.1016/S1474-4422(21)00159-9 4. Bril V et al. Lancet Neurol. 2023;22(5):383-394. doi:10.1016/S1474-4422(23)00077-7 5. Howard JF Jr et al. JAMA Neurol. 2020;77(5):582-592. doi:10.1001/jamaneurol.2019.5125 6. Howard JF Jr et al. Lancet Neurol. 2017;16(12):976-986. doi:10.1016/S1474-4422(17)30369-1 7. Sánchez-Tejerina et al. J Clin Med. 2022;11(21):6394. doi:10.3390/jcm11216394

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gMG=generalized myasthenia gravis.

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